Thanks, here's an excerpt

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Posted by John Behle on March 05, 2003 at 14:00:35:

In Reply to: Re: Found Aspirin pg. posted by Sarah on March 05, 2003 at 13:37:54:

Since Medscape makes you register, for those who are not yet registered, here is an excerpt from the article.

"A study of more than 250 people showed that most of those who took low-dose or coated aspirin in fact had no reduction in blood clotting, the researchers told a meeting of the American Stroke Association in Phoenix.

Full-sized, uncoated aspirin seemed more effective, based on measurement of platelet function, said Dr. Mark Alberts, director of the Stroke Program at Northwestern Memorial Hospital in Chicago.

"More than 50% of patients who got coated or low-dose aspirin seemed to have normal platelet function," Alberts said in a telephone interview. "This is remarkable."

He said his study would help explain why aspirin does not seem to work for many people. "About half the patients who have a heart attack or stroke are taking aspirin at the time," he said.

Alberts and colleagues tested 126 patients prescribed aspirin after having strokes. The patients were taking various doses and formulations of aspirin. Alberts found that 56% of those taking 81-milligram "baby" aspirin had no changes in blood clotting. But 72% of patients taking 325-mg aspirin pills had measurable effects.

He found 65% of patients taking coated aspirin -- no matter what the strength -- had no reduced clotting, while 75% patients taking uncoated aspirin did have reduced clotting.

Alberts said his study suggests that doctors may want to take the time to check to see whether aspirin is working in a patient, perhaps using the platelet test."


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